A strange but common issue is that the game crashes if your monitor is set to a high refresh rate (above 60Hz or 144Hz). Try capping your monitor to 60Hz or turning it off and back on right after launching the game. 3. Essential Optimization Tips
Most crashes occur because the game is looking for the old Games for Windows Live service. You can fix this by downloading a GFWL disabler or installing the Games for Windows Live Client manually.
Right-click re5dx9.exe in your game folder, select Properties > Compatibility , and set it to run in Windows 7 or Windows 8 mode. Also, check Run as administrator .