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Directed by Coralie Fargeat, The Substance stars Demi Moore as Elisabeth Sparkle, a fading celebrity who takes a black-market drug to create a younger, "better" version of herself, played by Margaret Qualley.

: As of October 2025, the film expanded its streaming presence to the Max platform. About the Movie Directed by Coralie Fargeat, The Substance stars Demi

: You can rent or buy the film directly through the Prime Video Store. Additionally, MUBI can be added as a Prime Video channel. Directed by Coralie Fargeat