Running high-performance software from a USB drive can lead to significant slowdowns unless using high-speed USB 3.0 or Type-C connections. Modern Alternatives for Mobility

Users gained the ability to see photorealistic graphics in real-time, a significant leap from the shaded-only models of previous years.

The introduction of Limit Mates allowed designers to capture more complex mechanical motions within their assemblies. System Requirements (Classic vs. Modern)

While 128 MB RAM was the minimum, 512 MB to 1 GB was recommended for assemblies with over 1,000 parts.

CAD software requires certified OpenGL graphics cards to function smoothly, which may not be available on every guest PC where a portable drive is plugged in.

If you need CAD capabilities on the go, modern alternatives have largely superseded the need for a portable version of a 20-year-old software:

Because it was built for the hardware of the early 2000s, the requirements are exceptionally low compared to modern CAD software: