This is common with older Prolific chipsets on Windows 10. To fix this, you may need to manually roll back to an older version of the Prolific driver (e.g., version 3.2.0.0 from 2007) via the Device Manager .
Look for "USB-Serial Controller" under Other devices or Ports (COM & LPT) . targus+pa088e+driver+windows+10+64+bit+link
Right-click the device and select Update driver . This is common with older Prolific chipsets on Windows 10
A Version 3.0.0 driver is hosted on the Targus BG repository specifically for the PA088E model. targus+pa088e+driver+windows+10+64+bit+link
Right-click the Start button and select Device Manager .